The disgraced former cyclist admitted taking performance-enhancing drugs in a two-part interview with Winfrey after years of denials.
Below are a selection of some of the best celebrity tweets from the past two nights:
CNN's Piers Morgan:
What a snivelling, lying, cheating little wretch @lancearmstrong revealed himself to be tonight. I hope he now just disappears.#LiveWrong
— Piers Morgan (@piersmorgan) January 18, 2013
Businessman and The Apprentice star Donald Trump:
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Lance Armstrong did himself great harm last night. Lawsuits & failure will follow him!
— Donald J. Trump (@realDonaldTrump) January 18, 2013
Comedian Joan Rivers:
Fair is fair. Lance Armstrong used performance-enhancing drugs to win the Tour de France while Oprah used him to win her time slot.
— Joan Rivers (@Joan_Rivers) January 18, 2013
Actor and comedian David Walliams:
The most disgusting part of the Lance Armstrong scandal was that his bicycle was fitted with stabilisers.
— David Walliams (@davidwalliams) January 19, 2013
Late night talk-show host Jimmy Fallon:
Thank you, Lance Armstrong, for sitting down with Oprah last night. I missed the interview, but I heard it was dope. #ThankYouNoteFriday
— jimmy fallon (@jimmyfallon) January 19, 2013
Comedian Albert Brooks:
When I rode tandem with Lance Armstrong I was on nothing.
— Albert Brooks (@AlbertBrooks) January 18, 2013
Sunday Times journalist David Walsh, author of Lance Armstrong book Seven Deadly Sins:
When he said he was behaving like a jerk during those years, I thought 'Lance, I could have told you that back then'.
— David Walsh (@DavidWalshST) January 18, 2013
Comedian Rob Delaney:
.@lancearmstrong I cheated on a vocab test in 9th grade, so I feel you brother. Ours is a lonely path. #strength
— rob delaney (@robdelaney) January 18, 2013
Parks And Recreation's Rashida Jones referenced the Manti Te'o story:
Great day for liars! They are dominating the news today. #CongratsUSA
— Rashida Jones (@iamrashidajones) January 18, 2013
Modern Family's Jesse Tyler Ferguson also mentioned the controversial quarterback:
I wonder if Manti Te'o ever got the "Thank You" bouquet that Lance Armstrong sent him.
— Jesse Tyler Ferguson (@jessetyler) January 18, 2013
Jack Osbourne takes a more contrary view of the scandal:
Honestly I don't care that Lance doped. He gave people hope and that's more important then anything. So what if he lied. #livestrong
— Jack Osbourne (@MrJackO) January 18, 2013
