The singer's new track 'What Do You Mean' is scheduled to arrive on Friday (August 28), and he'll swiftly follow that up with the first live performance of the song at the awards ceremony on Sunday (August 30).
Bieber has been counting down to the single's premiere for a month, describing the track as "really uplifting, clear, poppy, but cool".
He made his return to the stage at last weekend's Billboard Hot 100 Festival, nearly two years since the conclusion of his last major tour.
At one stage, it had been unclear whether the 21-year-old would ever return with new music, after he told a radio station at the end of 2013 that he was "actually retiring" - comments that were later "actually retiring".
Only @mileycyrus. Lol. It's true. I'm performing on the #vmas!! #bieberisback :) pic.twitter.com/vMBxudvSul
ā Justin Bieber (@justinbieber) August 27, 2015
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This year's MTV VMAs also includes performances from the likes of Pharrell Williams, Demi Lovato, Macklemore & Ryan Lewis, The Weeknd and A$AP Rocky.
Taylor Swift will also premiere her new video for 'Wildest Dreams' during the telecast, while Kanye West is receiving the Michael Jackson Video Vanguard Award for his impact on the industry.
Miley Cyrus will present the ceremony, and has been releasing a series of increasingly bonkers promos for her stint as host.
The 2015 MTV Video Music Awards air on Sunday live from the Microsoft
